I bought the book "The Strength of the Wolf: The Secret History of America's War on Drugs" by Douglas Valentine which covers the 1930-1968 period og national war on drugs, and it's interesting and rather detailed for the most part, but the only specific mention of a Chicago drug trafficking case in the early decades is this quote
Most of other references to early Chicago are vague.Chicago had earned its dubious reputation in 1925 when Elmer Irey arrested Narcotic Division Supervisor William Beech and three agents for selling seized drugs to gangsters.